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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > Diclofenac DiethylamineCAS：78213-16-8
Molecular Formula：C18H22Cl2N2O2
Molecular Weight：369.29
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 78213-16-8 |
| Name | Diclofenac Diethylamine |
| Molecular Formula | C18H22Cl2N2O2 |
| Molecular Weight | 369.29 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01862249 |
| SMILES | CCNCC.C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl |
| InChIKey | ZQVZPANTCLRASL-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H11Cl2NO2.C4H11N/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;1-3-5-4-2/h1-7，17H，8H2，(H，18，19);5H，3-4H2，1-2H3 |
| PubChem CID | 115087 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | It is an effective inhibitor of COX and has anti-inflammatory activity. |
| Biological Activity | Diclofenac Diethylamine 是一种有效的非选择性抗炎药，作为COX抑制剂，在CHO细胞中对人COX-1和COX-2的ic50分别为4和1.3 nM，对羊COX-1和COX-2的IC50分别为5.1和0.84 μM。通过激活caspase级联诱导神经干细胞(NSCs)凋亡。[1-3] |
| IC50 | Human COX-2: 1.5μM(IC50，in CHO cells);Human COX-1: 4nM(IC50，in CHO cells);Ovine COX-2: 0.84μM(IC50);Ovine COX-1: 5.1μM(IC50) [1-2] |
| Data Literature Source | [1]. Riendeau D，et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Labib MB，et al. Design，synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory，analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80. [3]. Kudo C，et al. Diclofenac inhibits proliferation and differentiation of neural stem cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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