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My CartCAS：23110-15-8
Molecular Formula：C26H34O7
Molecular Weight：458.54
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
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| CAS | 23110-15-8 |
| Name | Fumagillin |
| Molecular Formula | C26H34O7 |
| Molecular Weight | 458.54 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-433-8 |
| MDL | MFCD03990453 |
| SMILES | CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C |
| InChIKey | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| InChI | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3，33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13，19-20，23-24H，14-17H2，1-4H3，(H，27，28)/b7-5+，8-6+，11-9+，12-10+/t19-，20-，23-，24-，25+，26+/m1/s1 |
| PubChem CID | 6917655 |
| Target Point | Antibiotic |
| Passage | Anti-infection |
| Background | It is an antibiotic and a selective and effective irreversible inhibitor of MetAP2 (MetAP2). |
| Biological Activity | Fumagillin 是一种选择性且有效的甲硫氨酸胺基肽酶2(MetAP2)不可逆抑制剂，用作抗生素治疗微孢子虫病。[1] |
| Data Literature Source | [1]. Sin N，et al. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase，MetAP-2. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103. [2]. Sheen IS，et al. Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis. World J Gastroenterol. 2005 Feb 14;11(6):771-7. [3]. Watanabe N，et al. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 2006 May 15;580(11):2598-602. [4]. van den Heever JP，et al. Fumagillin: an overview of recent scientific advances and their significance for apiculture. J Agric Food Chem. 2014 Apr 2;62(13):2728-37. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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