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My Cart> Small Molecule Compounds > Anti-Infection > Anti-Parasite > Mefloquine HydrochlorideCAS：51773-92-3
Molecular Formula：C17H17ClF6N2O
Molecular Weight：414.77
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 51773-92-3 |
| Name | Mefloquine Hydrochloride |
| Molecular Formula | C17H17ClF6N2O |
| Molecular Weight | 414.77 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 257-412-0 |
| MDL | MFCD00797519 |
| SMILES | C1CCNC(C1)C(C2=CC(=NC3=C2C=CC=C3C(F)(F)F)C(F)(F)F)O.Cl |
| InChIKey | WESWYMRNZNDGBX-YLCXCWDSSA-N |
| InChI | InChI=1S/C17H16F6N2O.ClH/c18-16(19，20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21，22)23)25-14(9)11;/h3-5，8，12，15，24，26H，1-2，6-7H2;1H/t12-，15+;/m1./s1 |
| PubChem CID | 65329 |
| Target Point | Parasite;SARS-CoV;Potassium Channel |
| Passage | Anti-infection;Membrane Transporter&Ion Channel |
| Background | Mefloquine Hydrochloride is an quinoline antimalarial compound and an anti-SARS-COV-2 entry inhibitor. Mefloquine hydrochloride is used as a K+ channel (KvQT1/minK) antagonist. Mefloquine hydrochloride is used to study malaria, systemic lupus erythematosus, and cancer. |
| Biological Activity | Mefloquin hydrochloride 是一种喹啉类抗疟药，是一种抗 SARS-CoV-2 进入抑制剂，也是一种 K+ 通道（KvQT1/minK）拮抗剂，IC50 约为 1 μM，可用于疟疾、系统性红斑狼疮和癌症研究。[1-3] |
| Data Literature Source | [1]. Kang J，et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. [2]. Yan KH，et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt，ERK，JNK and AMPK signaling. Oncol Lett. 2013 May;5(5):1541-1545. [3]. Shionoya K，et al. Mefloquine，a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403. [4]. Pacheco-Costa R，et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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