CAS:82752-99-6
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
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Nefazodone HydrochlorideCAS:82752-99-6
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 82752-99-6 |
Chinese Name | 萘法唑酮盐酸盐 |
English Name | Nefazodone Hydrochloride |
Synonyms | Serzone;Dutonin;BMY-13754;MJ-13754-1 |
Molecular Formula | C25H33Cl2N5O2 |
Molecular Weight | 506.47 |
Solubility | Soluble in DMSO(Need ultrasonic) |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD00935760 |
SMILES | CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl.Cl |
InChIKey | DYCKFEBIOUQECE-UHFFFAOYSA-N |
InChI | InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H |
PubChem CID | 54911 |
Target Point | 5-HT Receptor |
Passage | Neuronal Signaling;GPCR & G Protein |
Background | It is a potent and selective 5HT2A antagonist with moderate inhibition of 5-HT and norepinephrine uptake. It has antidepressant activity. |
Biological Activity | Nefazodone Hydrochloride 是一种强效、选择性的 5HT2A 拮抗剂(Ki=5.8 nM),对 5-HT 和去甲肾上腺素的摄取有中度抑制作用(IC50 分别为 290 nM 和 300 nM)。也是一种苯丙哌嗪类抗抑郁药,α-肾上腺素能阻断活性较低。[1-2] |
In Vitro | 盐酸奈法佐酮是一种苯基哌嗪类抗抑郁药,其作用机制与目前市面上的其他药物不同。盐酸奈法唑酮能有效并选择性地阻断突触后血清素(5-羟色胺;5-HT)5-HT2A 受体,并适度抑制血清素和去甲肾上腺素(去甲肾上腺素)的再摄取。盐酸奈法佐酮还是肝脏 P-450 同工酶 CYP3A4 的抑制剂。[2] |
Data Literature Source | [1]. Pullar IA,et al. LY367265,an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine(2A) receptor antagonist: a comparison with the antidepressant,nefazodone. Eur J Pharmacol. 2000 Oct 27;407(1-2):39-46. [2]. Ellingrod VL,et al. Nefazodone: a new antidepressant. Am J Health Syst Pharm. 1995 Dec 15;52(24):2799-812. |
Unit | Bottle |
Specification | 5mg 10mg |