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My CartCAS：1041434-82-5
Molecular Formula：C15H34N4O7
Molecular Weight：382.45
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1041434-82-5 |
| Name | Peramivir Trihydrate |
| Molecular Formula | C15H34N4O7 |
| Molecular Weight | 382.45 |
| Solubility | Soluble in Water ≥2mg/mL(Need ultrasonic);Soluble in DMSO ＜ 1mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD22417093 |
| SMILES | CCC(CC)[C@@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O |
| InChIKey | RFUCJKFZFXNIGB-ZBBHRWOZSA-N |
| InChI | InChI=1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13，21H，4-6H2，1-3H3，(H，18，20)(H，22，23)(H4，16，17，19);3*1H2/t9-，10+，11+，12-，13+;;;/m0.../s1 |
| PubChem CID | 11954371 |
| Target Point | Influenza Virus |
| Passage | Anti-infection |
| Background | Peramivir trihydrate (RWJ-270201 trihydrate;BCX-1812 trihydrate) is a highly potent， selective and orally active influenza virus neuraminidase (NA) inhibitor， with IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes[1-2]. |
| Biological Activity | Peramivir Trihydrate 是一种高效、选择性和口服活性流感病毒神经氨酸酶（NA）抑制剂，对 NA 亚型的 IC50 值介于 0.9 至 4.3 nM 之间三。[1-2] |
| IC50 | NA：0.9-4.3nM(IC50)[1] |
| Data Literature Source | [1]. Young D，et al. RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1905-13. [2]. Yun NE，et al. Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus，A/Vietnam/1203/04 (H5N1). Virology. 2008 Apr 25;374(1):198-209. [3]. Smee DF，et al. Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice. Antiviral Res. 2010 Oct;88(1):38-44. [4]. Boltz DA，et al. Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice. Antiviral Res. 2008 Nov;80(2):150-7. [5]. Tarbet EB，et al. Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice. Antiviral Res. 2012 Apr;94(1):103-10. [6]. Bantia S，et al. Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model. Antiviral Res. 2010 Dec;88(3):276-80. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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