CAS:91374-20-8
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Light yellow to yellow Solid
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Ropinirole HydrochlorideCAS:91374-20-8
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Light yellow to yellow Solid
CAS | 91374-20-8 |
Chinese Name | 盐酸罗匹尼罗 |
English Name | Ropinirole Hydrochloride |
Synonyms | SKF-101468A;SKF 101468 hydrochloride |
Molecular Formula | C16H25ClN2O |
Molecular Weight | 296.84 |
Solubility | Soluble in Water/DMSO(Need ultrasonic) |
Purity | ≥98% |
Appearance | Light yellow to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD01754173 |
SMILES | CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1.Cl |
InChIKey | XDXHAEQXIBQUEZ-UHFFFAOYSA-N |
InChI | InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H |
PubChem CID | 68727 |
Target Point | Dopamine Receptor |
Passage | Neuronal Signaling;GPCR & G Protein |
Background | It is a selective D2 receptor inhibitor and has the potential to be used in Parkinsons disease. |
Biological Activity | Ropinirole Hydrochloride 是一种口服活性强效 D3/D2 受体激动剂,对 D2 受体的 Ki 值为 29 nM,对 hD2、hD3 和 hD4 受体的 pEC50 分别为 7.4、8.4 和 6.8,对 D1 受体没有亲和力,具有治疗帕金森病的潜力。[1-2] |
In Vitro | 盐酸罗匹尼罗对 D2 受体的 Ki 为 2.9 x 10(-8)M,而对大鼠 D1 受体的亲和力为 10(-4)M。罗匹尼罗对α2-肾上腺素受体和 5-HT2 受体的活性较弱,但对 5-HT1、苯并二氮杂卓和γ-氨基丁酸受体或α1 和β-肾上腺素受体无活性。[1] |
In Vivo | 盐酸罗匹尼罗(0.05-1.0 毫克/千克 SC 或 0.1 毫克/千克)可逆转 MPTP 引起的所有运动和行为障碍。这种反应从给药后 10-20 分钟开始,持续时间超过 2 小时。[1]盐酸罗匹尼罗(0、0.1、1 或 10 毫克/千克,静脉注射,大鼠)降低了ICSS阈值,并诱导了类似抗焦虑和抗抑郁的作用,但不影响运动活动或空间记忆。[2] |
Data Literature Source | [1]. Eden RJ,et al. Preclinical pharmacology of ropinirole (SK&F 101468-A) a novel dopamine D2 agonist. Pharmacol Biochem Behav. 1991 Jan;38(1):147-54. [2]. Mavrikaki M,et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93. |
Unit | Bottle |
Specification | 25mg |