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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > RotigotineCAS：99755-59-6
Molecular Formula：C19H25NOS
Molecular Weight：315.47
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 99755-59-6 |
| Name | Rotigotine |
| Molecular Formula | C19H25NOS |
| Molecular Weight | 315.47 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00869590 |
| SMILES | CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O |
| InChIKey | KFQYTPMOWPVWEJ-INIZCTEOSA-N |
| InChI | InChI=1S/C19H25NOS/c1-2-11-20(12-10-17-6-4-13-22-17)16-8-9-18-15(14-16)5-3-7-19(18)21/h3-7，13，16，21H，2，8-12，14H2，1H3/t16-/m0/s1 |
| PubChem CID | 59227 |
| Target Point | Dopamine Receptor;5-HT Receptor;Adrenergic Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein;Endocrinology & Hormones |
| Background | It is an effective dopamine receptor agonist, partial agonist of 5-HT1A receptor and antagonist of α2B-adrenergic receptor; It can be used for related research of Parkinsons disease (PD). |
| Biological Activity | Rotigotine 是一种多巴胺受体激动剂 (dopamine receptor)，对多巴胺D2、D3、D4和D5受体具有高亲和力，但对多巴胺D1受体的亲和力较低，其 Ki 值为 0.71 nM (dopamine D3 receptor)，4-15 nM (D2，D5，D4 receptors)，83 nM (dopamine D1 receptor)，也是 5-HT1A receptor 的部分激动剂和 α2B-adrenergic receptor 的拮抗剂，可用于帕金森病（PD）研究。[1-4] |
| Data Literature Source | [1]. Wood M，et al. Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors. Br J Pharmacol. 2015 Feb;172(4):1124-35. [2]. Radad K，et al. Neuroprotective effect of rotigotine against complex I inhibitors，MPP and rotenone，in primary mesencephalic cell culture. Folia Neuropathol. 2014;52(2):179-86. [3]. Bertaina-Anglade V，et al. Antidepressant properties of rotigotine in experimental models of depression. Eur J Pharmacol. 2006 Oct 24;548(1-3):106-14. [4]. Scheller D，et al. The in vitro receptor profile of rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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