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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > Roxatidine Acetate HydrochlorideCAS：93793-83-0
Molecular Formula：C19H29ClN2O4
Molecular Weight：384.9
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 93793-83-0 |
| Name | Roxatidine Acetate Hydrochloride |
| Molecular Formula | C19H29ClN2O4 |
| Molecular Weight | 384.9 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00941429 |
| SMILES | CC(=O)OCC(=O)NCCCOC1=CC=CC(=C1)CN2CCCCC2.Cl |
| InChIKey | FEWCTJHCXOHWNL-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H28N2O4.ClH/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21;/h5，7-8，13H，2-4，6，9-12，14-15H2，1H3，(H，20，23);1H |
| PubChem CID | 56704 |
| Target Point | Histamine H2 Receptor |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It is a specific, competitive histamine H2 receptor antagonist. |
| Biological Activity | Roxatidine Acetate Hydrochloride 是一种有效的、选择性的、竞争性的、具有口服活性的组胺 H2 受体（histamine H2-receptor）拮抗剂，还能抑制炎症反应，可用于胃溃疡和十二指肠溃疡的研究，并可通过减少血管内皮生长因子（VEGF）的表达来抑制多种肿瘤的生长。[1-3] |
| Data Literature Source | [1]. Murdoch D，et al. A review of its pharmacodynamic and pharmacokinetic properties，and its therapeutic potential in peptic ulcer disease and related disorders. Drugs. 1991 Aug;42(2):240-60. [2]. Cho EJ，et al. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem. 2011 Dec;112(12):3648-59. [3]. Tomita K，et al. Roxatidine- and cimetidine-induced angiogenesis inhibition suppresses growth of colon cancer implants in syngeneic mice. J Pharmacol Sci. 2003 Nov;93(3):321-30. [4]. Lee M，et al. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017 Jan 31;7:41721. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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