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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > SulfisoxazoleCAS：127-69-5
Molecular Formula：C11H13N3O3S
Molecular Weight：267.3
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 127-69-5 |
| Name | Sulfisoxazole |
| Molecular Formula | C11H13N3O3S |
| Molecular Weight | 267.3 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-858-9 |
| MDL | MFCD00003150 |
| SMILES | CC1=C(ON=C1C)NS(=O)(=O)C2=CC=C(C=C2)N |
| InChIKey | NHUHCSRWZMLRLA-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15，16)10-5-3-9(12)4-6-10/h3-6，14H，12H2，1-2H3 |
| PubChem CID | 5344 |
| Target Point | Endothelin receptor;Bacterial |
| Passage | GPCR&G Protein;Anti-infection |
| Background | It is an antagonist for endothelin receptor A to inhibit exon release in breast cancer by targeting endothelin receptor A. It is also a sulfa antibacterial compound. |
| Biological Activity | Sulfisoxazole 是内皮素受体（endothelin receptor）拮抗剂，对内皮素受体 A 和 B 的IC50 值分别为 0.60 μM 和 22 μM，是磺胺类抗菌剂（antibacterial），通过靶向内皮素受体 A，抑制乳腺癌外显子释放。[1-2] |
| IC50 | ETA: 0.60μM(IC50);ETB: 22μM(IC50) [1] |
| Data Literature Source | [1]. Chan MF，et al. Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun. 1994 May 30;201(1):228-34. [2]. Im EJ，et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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