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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > TropisetronCAS：89565-68-4
Molecular Formula：C17H20N2O2
Molecular Weight：284.35
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 89565-68-4 |
| Name | Tropisetron |
| Molecular Formula | C17H20N2O2 |
| Molecular Weight | 284.35 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00864399 |
| SMILES | CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43 |
| InChIKey | ZNRGQMMCGHDTEI-FUNVUKJBSA-N |
| InChI | InChI=1S/C17H20N2O2/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16/h2-5，10-13，18H，6-9H2，1H3/t11-，12+，13? |
| PubChem CID | 656665 |
| Target Point | 5-HT Receptor;nAChR |
| Passage | Neuronal Signaling；GPCR & G Protein;Membrane Transporter&Ion Channel |
| Background | It is a 5-HT3 receptor antagonist and also an α7-nicotinic receptor agonist. |
| Biological Activity | Tropisetron 是一种α7烟碱受体激动剂，同时也是5-羟色胺（5-HT）3 受体拮抗剂，IC50为70.1 nM，具有镇痛和抗炎活性。[1] |
| IC50 | 5-HT3 Receptor：70.1μM(IC50)[1] |
| Data Literature Source | [1]. Macor JE，et al. The 5-HT3 antagonist tropisetron (ICS 205-930) is a potent and selective alpha7 nicotinic receptor partial agonist. Bioorg Med Chem Lett. 2001 Feb 12;11(3):319-21. [2]. Vega Lde L，et al. The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway. Biochem Pharmacol. 2005 Aug 1;70(3):369-80. [3]. Stratz C，et al. The anti-inflammatory effects of the 5-HT receptor antagonist tropisetron are mediated by the inhibition of p38 MAPK activation in primary human monocytes. Int Immunopharmacol. 2012 Aug;13(4):398-402. [4]. Candelario-Jalil E，et al. Detrimental effects of tropisetron on permanent ischemic stroke in the rat. BMC Neurosci. 2008 Feb 6;9:19. doi: 10.1186/1471-2202-9-19. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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