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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > ZaltoprofenCAS：74711-43-6
Molecular Formula：C17H14O3S
Molecular Weight：298.36
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 74711-43-6 |
| Name | Zaltoprofen |
| Molecular Formula | C17H14O3S |
| Molecular Weight | 298.36 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00864323 |
| SMILES | CC(C1=CC2=C(C=C1)SC3=CC=CC=C3C(=O)C2)C(=O)O |
| InChIKey | MUXFZBHBYYYLTH-UHFFFAOYSA-N |
| InChI | InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8，10H，9H2，1H3，(H，19，20) |
| PubChem CID | 5720 |
| Target Point | COX-2 |
| Passage | Immunology & Inflammation |
| Background | It is a COX-2 inhibitor, which also has an inhibitory effect on COX-1, anti-inflammatory activity and analgesic effect on inflammatory pain. |
| Biological Activity | Zaltoprofen 是一种具有优先口服活性的 COX-2 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 1.3 和 0.34 μM。是一种非甾体抗炎药（NSAID），具有强大的抗炎作用，并对炎性疼痛有镇痛作用。[1-3] |
| IC50 | COX-1: 1.3μM(IC50);COX-2: 0.34μM(IC50) [1] |
| Data Literature Source | [1]. Kawai S，et al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur J Pharmacol. 1998 Apr 17;347(1):87-94. [2]. Hirate K，et al. Zaltoprofen，a non-steroidal anti-inflammatory drug，inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res. 2006 Apr;54(4):288-94. [3]. Kameyama T，et al. Analgesic and antiinflammatory effects of 2-(10，11-dihydro-10-oxo-dibenzo[b，f]thiepin-2-yl)propionic acid in rat and mouse. Arzneimittelforschung. 1987 Jan;37(1):19-26. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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