| CAS |
636-00-0 |
| Chinese Name |
6-羟基多巴胺氢溴酸盐 |
| English Name |
6-Hydroxy DopaMine HydrobroMide |
| Synonyms |
2，4，5-trihydroxyphenethylamine;6-Hydroxydopamine hydrobromide;6-OHDA hydrobromide;Oxidopamine hydrobromide |
| Molecular Formula |
C8H12BrNO3 |
| Molecular Weight |
250.09 |
| Solubility |
Soluble in Water/DMSO(Need ultrasonic) |
| Purity |
≥98% |
| Appearance |
Solid |
| Storage |
Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC |
EINECS 211-247-0 |
| MDL |
MFCD00012894 |
| SMILES |
C1=C(C(=CC(=C1O)O)O)CCN.Br |
| InChIKey |
MLACDGUOKDOLGC-UHFFFAOYSA-N |
| InChI |
InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4，10-12H，1-2，9H2;1H |
| PubChem CID |
176170 |
| Target Point |
Dopamine Receptor |
| Passage |
Neuronal Signaling;GPCR & G Protein |
| Background |
6-Hydroxy DopaMine HydrobroMide, an antagonist of the neurotransmitter dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons. |
| Biological Activity |
6-Hydroxy DopaMine HydrobroMide 是一种多巴胺神经递质拮抗剂，是一种广泛使用的神经毒素，可选择性地破坏多巴胺能神经元。可促进 COX-2 的活化，导致 PGE2 的合成和促炎细胞因子 IL-1β 的分泌。氢溴酸氧化多巴胺可用于帕金森病（PD）、注意力缺陷多动障碍（ADHD）。[1-3] |
| In Vitro |
PGE2 receptor EP2 is a key mediator of COX-2 activity-initiated cAMP signaling in Neuro-2a and SH-SY5Y cells following 6-Hydroxy DopaMine HydrobroMide(6-OHDA)treatment，and contributes to oxidopamine-mediated neurotoxicity.[1] Treatment of PC12 cells with 6-OHDA resulted in the activation of caspases and apoptosis. 6-OHDA also induced superoxide generation，Bid cleavage and mitochondrial membrane depolarization. In addition，Akt phosphorylation that was favorable to cell survival was decreased and p38 MAPK phosphorylation was increased by 6-OHDA. LY294002，an inhibitor of Akt upstream molecule PI3-kinase，enhanced 6-OHDA-induced apoptosis.[3] |
| In Vivo |
Resveratrol significantly attenuated apomorphine-induced turns of rats in 6-OHDA(5 microg/2 microl)-injuried Parkinson's disease rat model as early as two weeks of administration. Resveratrol (10，20 and 40 mg/kg)alleviated 6-OHDA-induced chromatin condensation，mitochondrial tumefaction and vacuolization of dopaminergic neurons in rat substantia nigra.[2] |
| Animal Experiment |
Adult Sprague-Dawley(SD)rats were unilaterally injected with 6-OHDA(5 microg/2 microl)into the right striatum，and the striatum damage was assessed by rotational test，ultrahistopathology，and molecular alterations. Resveratrol(10，20 and 40 mg/kg)was then given orally to Parkinson's disease rats，daily for 10 weeks to examine the protective effects.[2] |
| Data Literature Source |
[1]. Kang X，et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459.
[2]. Jin F，et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600(1-3):78-82.
[3]. Fujita H，et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. |
| Unit |
Bottle |
| Specification |
50mg 100mg |
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