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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > 6-Hydroxy DopaMine HydrobroMideCAS：636-00-0
Molecular Formula：C8H12BrNO3
Molecular Weight：250.09
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 636-00-0 |
| Name | 6-Hydroxy DopaMine HydrobroMide |
| Molecular Formula | C8H12BrNO3 |
| Molecular Weight | 250.09 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 211-247-0 |
| MDL | MFCD00012894 |
| SMILES | C1=C(C(=CC(=C1O)O)O)CCN.Br |
| InChIKey | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4，10-12H，1-2，9H2;1H |
| PubChem CID | 176170 |
| Target Point | Dopamine Receptor |
| Passage | Neuronal Signaling;GPCR & G Protein |
| Background | 6-Hydroxy DopaMine HydrobroMide, an antagonist of the neurotransmitter dopamine, is a widely used neurotoxin that selectively destroys dopaminergic neurons. |
| Biological Activity | 6-Hydroxy DopaMine HydrobroMide 是一种多巴胺神经递质拮抗剂，是一种广泛使用的神经毒素，可选择性地破坏多巴胺能神经元。可促进 COX-2 的活化，导致 PGE2 的合成和促炎细胞因子 IL-1β 的分泌。氢溴酸氧化多巴胺可用于帕金森病（PD）、注意力缺陷多动障碍（ADHD）。[1-3] |
| Data Literature Source | [1]. Kang X，et al. Cyclooxygenase-2 contributes to oxidopamine-mediated neuronal inflammation and injury via the prostaglandin E2 receptor EP2 subtype. Sci Rep. 2017 Aug 25;7(1):9459. [2]. Jin F，et al. Neuroprotective effect of resveratrol on 6-OHDA-induced Parkinson's disease in rats. Eur J Pharmacol. 2008 Dec 14;600(1-3):78-82. [3]. Fujita H，et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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