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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Adiphenine HydrochlorideCAS：50-42-0
Molecular Formula：C20H26ClNO2
Molecular Weight：347.88
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 50-42-0 |
| Name | Adiphenine Hydrochloride |
| Molecular Formula | C20H26ClNO2 |
| Molecular Weight | 347.88 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-036-9 |
| MDL | MFCD00242658 |
| SMILES | CCN(CC)CCOC(=O)C(C1=CC=CC=C1)C2=CC=CC=C2.Cl |
| InChIKey | LKPINBXAWIMZCG-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H25NO2.ClH/c1-3-21(4-2)15-16-23-20(22)19(17-11-7-5-8-12-17)18-13-9-6-10-14-18;/h5-14，19H，3-4，15-16H2，1-2H3;1H |
| PubChem CID | 5763 |
| Target Point | nAChR |
| Passage | Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | It is a nicotinic receptor inhibitor. |
| Biological Activity | Adiphenine Hydrochloride 是烟碱乙酰胆碱受体（nAChR）的非竞争性抑制剂，对α1、α3β4、α4β2 和 α4β4的 IC50 分别为 1.9、1.8、3.7 和 6.3 μM，具有抗惊厥作用[1-3]。 |
| IC50 | α1nAChR: 1.9μM(IC50);α3β4nAChR: 1.8μM(IC50);α4β2nAChR: 3.7μM(IC50);α4β4nAChR: 6.3μM(IC50) [1] |
| Data Literature Source | [1]. Gentry CL，et al. Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48. [2]. Spitzmaul G，et al. The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol. 2009 Jul;157(5):804-17. doi: 10.1111/j.1476-5381.2009.00214.x. Epub 2009 Apr 30. [3]. Michelot J，et al. Adiphenine plasma levels and blood-brain barrier crossing in the rat. Eur J Drug Metab Pharmacokinet. 1985 Oct-Dec;10(4):273-8. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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