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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > ClemizoleCAS：442-52-4
Molecular Formula：C19H20ClN3
Molecular Weight：325.84
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 442-52-4 |
| Name | Clemizole |
| Molecular Formula | C19H20ClN3 |
| Molecular Weight | 325.84 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 207-133-5 |
| MDL | MFCD00051434 |
| SMILES | C1CCN(C1)CC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)Cl |
| InChIKey | CJXAEXPPLWQRFR-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H20ClN3/c20-16-9-7-15(8-10-16)13-23-18-6-2-1-5-17(18)21-19(23)14-22-11-3-4-12-22/h1-2，5-10H，3-4，11-14H2 |
| PubChem CID | 2782 |
| Target Point | Histamine H1 receptor;TRPC5 |
| Passage | GPCR & G Protein;Neuronal Signaling;Immunology & Inflammation |
| Background | It is an H1 histamine receptor antagonist and can inhibit the RNA binding of NS4B and HCV replication. It is also an inhibitor of the TRPC5 channel. |
| Biological Activity | Clemizole 是一种 H1 组胺受体拮抗剂，可大幅抑制 HCV 复制，是 TRPC5 通道的抑制剂，与 NS4B 的 RNA 结合的 IC50 为 24±1 nM，对病毒复制的 EC50 为 8 μM。[1-2] |
| IC50 | NS4B: 24nM(IC50)[1] |
| Data Literature Source | [1]. Einav S，et al. Discovery of a hepatitis C target and its pharmacological inhibitors by microfluidic affinity analysis. Nat Biotechnol. 2008 Sep;26(9):1019-27. [2]. Richter JM，et al. Clemizole hydrochloride is a novel and potent inhibitor of transient receptor potential channel TRPC5. Mol Pharmacol. 2014 Nov;86(5):514-21. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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