{{cart_num}}
My CartCAS：72822-13-0
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 72822-13-0 |
| Name | Dapiprazole Hydrochloride |
| Molecular Formula | C19H28ClN5 |
| Molecular Weight | 361.91 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00941400 |
| SMILES | CC1=CC=CC=C1N2CCN(CC2)CCC3=NN=C4N3CCCC4.Cl |
| InChIKey | ZIODNPFQZIHCOE-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H27N5.ClH/c1-16-6-2-3-7-17(16)23-14-12-22(13-15-23)11-9-19-21-20-18-8-4-5-10-24(18)19;/h2-3，6-7H，4-5，8-15H2，1H3;1H |
| PubChem CID | 6917787 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is an effective, selective and orally active alpha-1 adrenoceptor antagonist. |
| Biological Activity | Dapiprazole Hydrochloride 是一种强效、选择性和口服活性α-1肾上腺素受体拮抗剂，可抑制阿片类戒断症状，也可作为眼药水用于逆转瞳孔放大。[1-3] |
| In Vivo | Dapiprazole hydrochloride(0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once)depresses registered the naloxone precipitated withdrawal syndrome. [1] Dapiprazole hydrochloride 0.5% eye drops are effective and safe in reversing mydriasis after instillation of tropicamide 1% and phenylephrine 2.5%.[2] 0.5% dapiprazole hydrochloride eyedrops had a sympatholytic effect on the pupil.[3] |
| Data Literature Source | [1]. Valeri P，et al. Effects of dapiprazole，clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [2]. Allinson RW，et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3，138. [3]. Hou RH，et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Manual Download
