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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > Hexamethonium DibromideCAS：55-97-0
Molecular Formula：C12H30Br2N2
Molecular Weight：362.19
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 55-97-0 |
| Name | Hexamethonium Dibromide |
| Molecular Formula | C12H30Br2N2 |
| Molecular Weight | 362.19 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-249-7 |
| MDL | MFCD00011787 |
| SMILES | C[N+](C)(C)CCCCCC[N+](C)(C)C.[Br-].[Br-] |
| InChIKey | FAPSXSAPXXJTOU-UHFFFAOYSA-L |
| InChI | InChI=1S/C12H30N2.2BrH/c1-13(2，3)11-9-7-8-10-12-14(4，5)6;;/h7-12H2，1-6H3;2*1H/q+2;;/p-2 |
| PubChem CID | 5938 |
| Target Point | nAChR |
| Passage | Neuronal Signaling;Membrane Transporter&Ion Channel |
| Background | It is a non-selective ganglion nicotinic receptor (nAChR) antagonist. |
| Biological Activity | Hexamethonium Bromide 是一种非选择性的神经节烟碱受体 (nAChR) 拮抗剂，具有竞争性和非竞争性活性。具有降压作用，能降低其交感神经活动和血压。[1-3] |
| Data Literature Source | [1]. Hawkins BT，et al. Modulation of cerebral microvascular permeability by endothelial nicotinic acetylcholine receptors. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H212-9. [2]. Li P，et al. Hexamethonium attenuates sympathetic activity and blood pressure in spontaneously hypertensive rats. Mol Med Rep. 2015 Nov;12(5):7116-22. [3]. Papke RL，et al. Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther. 2010 May;333(2):501-18. |
| Unit | Bottle |
| Specification | 250mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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