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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > KetorolacCAS：74103-06-3
Molecular Formula：C15H13NO3
Molecular Weight：255.27
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 74103-06-3 |
| Name | Ketorolac |
| Molecular Formula | C15H13NO3 |
| Molecular Weight | 255.27 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00864281 |
| SMILES | C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O |
| InChIKey | OZWKMVRBQXNZKK-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7，11H，8-9H2，(H，18，19) |
| PubChem CID | 3826 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | It is a nonsteroidal anti-inflammatory compound and a nonselective COX inhibitor. |
| Biological Activity | Ketorolac 是一种非选择性 COX 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为20 nM 和 120 nM，是一种 DDX3 抑制剂，可用于癌症研究，也是一种非甾体抗炎药。[1-4] |
| IC50 | COX-1: 20nM(IC50);COX-2: 120nM(IC50)[1] |
| Data Literature Source | [1]. Waterbury LD，et alT. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. [2]. Fracon RN，et al. Treatment with paracetamol，ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. [3]. Hsieh YC，et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-1139. [4]. Samal SK，et al. Ketorolac salt is a newly discovered DDX3 inhibitor to treat oral cancer. Sci Rep. 2015 Apr 28;5:9982. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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