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My CartCAS：550-99-2
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 550-99-2 |
| Name | Naphazoline Hydrochloride |
| Molecular Formula | C14H15ClN2 |
| Molecular Weight | 246.74 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 208-989-2 |
| MDL | MFCD00012554 |
| SMILES | C1CN=C(N1)CC2=CC=CC3=CC=CC=C32.Cl |
| InChIKey | DJDFFEBSKJCGHC-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H，8-10H2，(H，15，16);1H |
| PubChem CID | 11079 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is an effective alpha-Adrenergic receptor agonist. |
| Biological Activity | Naphazoline Hydrochloride 是一种α-肾上腺素能受体激动剂，盐酸萘甲唑啉可降低血管高渗透性，促进血管收缩，可降低炎症因子（TNF-α、IL-1β 和 IL-6）、细胞因子（IFN-γ 和 IL-4）、IgE、GMCSF 和 NGF 的水平。[1-2] |
| In Vivo | In allergic conjunctivitis mouse model，which mice were treated with 0.2 mg/ml of naphazoline hydrochloride，significantly suppressed conjunctival dye leakage in mice with histamine or antigen induced conjunctival vascular hyperpermeability，and the protein expression levels of VEGF in antigen induced conjunctival vascular hyperpermeability mice were reduced.[1] Naphazoline stimulates central alpha adrenergic receptors which has a tonic inhibiting role in rat gastric secretion. The ED50 of i.c.v. naphazoline was 12.3 times less than that of s.c. dose.[2] |
| Data Literature Source | [1]. Quan L，et al. Treatment with olopatadine and naphazoline hydrochloride reduces allergic conjunctivitis in mice through alterations in inflammation，NGF and VEGF. Mol Med Rep. 2016 Apr;13(4):3319-25. [2]. Yamaguchi I，et al. Central and peripheral adrenergic mechanisms regulating gastric secretion in the rat. J Pharmacol Exp Ther. 1977 Oct;203(1):125-31. |
| Unit | Bottle |
| Specification | 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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