CAS:407-41-0
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
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O-Phospho-L-serineCAS:407-41-0
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 407-41-0 |
Chinese Name | O-磷酸-L-丝氨酸 |
English Name | O-Phospho-L-serine |
Synonyms | Dexfosfoserine;磷酸化丝氨酸;L-SOP |
Molecular Formula | C3H8NO6P |
Molecular Weight | 185.07 |
Solubility | Soluble in Water(Need ultrasonic) |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 206-986-0 |
MDL | MFCD00065935 |
SMILES | C(C(C(=O)O)N)OP(=O)(O)O |
InChIKey | BZQFBWGGLXLEPQ-REOHCLBHSA-N |
InChI | InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1 |
PubChem CID | 68841 |
Target Point | mGluR |
Passage | Neuronal Signaling;GPCR & G Protein |
Background | O-Phospho-L-serine is an agonist for mGluR4, mGluR6, mGluR7, and mGluR8, and an antagonist for mGluR1 and mGluR2. |
Biological Activity | O-Phospho-L-serine 是 L-丝氨酸的前体物质,是mGluR4、mGluR6、mGluR7 和 mGluR8 的激动剂,mGluR1 的弱拮抗剂和 mGluR2 的强拮抗剂。[1-3] |
In Vitro | O-磷酸-L-丝氨酸(L-SOP)与 mGluR1 的结合力很弱。L-SOP 能激活第 III 组受体(mGluR4、mGluR6、mGluR7 和 mGluR8),但 mGluR7 对 L-SOP 的亲和力远低于其他第 III 组受体,对两种配体的效力也较低。[1]L-SOP激活第三组 mGluR,尤其是 mGluR4、-6、-8,但不能激活mGluR1 或 mGluR2,但它对 mGluR1 起着微弱的拮抗作用,对 mGluR2 起着强效的拮抗作用。[2] L-SOP能部分阻断小胶质细胞对凋亡细胞的吞噬作用。[3] |
Data Literature Source | [1]. Kang HJ,et al. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30;290(5):2870-8. [2]. Kang HJ,et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24;289(43):29961-74. [3]. Bailey TJ,et al. The inhibitor of phagocytosis,O-phospho-L-serine,suppresses Müller glia proliferation and cone cell regeneration in the light-damaged zebrafish retina. Exp Eye Res. 2010 Nov;91(5):601-12. |
Unit | Bottle |
Specification | 100mg |