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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Neuronal Signal Pathway > PerphenazineCAS：58-39-9
Molecular Formula：C21H26ClN3OS
Molecular Weight：403.97
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 58-39-9 |
| Name | Perphenazine |
| Molecular Formula | C21H26ClN3OS |
| Molecular Weight | 403.97 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 200-381-5 |
| MDL | MFCD00056798 |
| SMILES | C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO |
| InChIKey | RGCVKNLCSQQDEP-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H26ClN3OS/c22-17-6-7-21-19(16-17)25(18-4-1-2-5-20(18)27-21)9-3-8-23-10-12-24(13-11-23)14-15-26/h1-2，4-7，16，26H，3，8-15H2 |
| PubChem CID | 4748 |
| Target Point | Dopamine Receptor;Histamine Receptor |
| Passage | Neuronal Signaling；GPCR & G Protein;Immunology & Inflammation |
| Background | It is an antagonist to the dopamine receptor and histamine-1 receptor. |
| Biological Activity | Perphenazine 是一种口服活性多巴胺受体和组胺 H-1 受体拮抗剂，其 Ki 值分别为 0.56 nM（D2）、0.43 nM（D3）和 6 nM（5-HT2A），能与肾上腺素 Alpha-1A 受体结合，还能抑制癌细胞增殖并诱导细胞凋亡。[1-3]。 |
| Data Literature Source | [1]. Tao L，et al. Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo. Toxicol Lett. 2022 Aug 15;367:76-87. [2]. Heo MJ，et al. Perphenazine Attenuates the Pro-Inflammatory Responses in Mouse Models of Th2-Type Allergic Dermatitis. Int J Mol Sci. 2020 May 3;21(9):3241. [3]. Otr ba M，et al. Perphenazine and prochlorperazine decrease glioblastoma U-87 MG cell migration and invasion: Analysis of the ABCB1 and ABCG2 transporters，E-cadherin，α-tubulin and integrins (α3，α5，and β1) levels. Oncol Lett. 2022 Jun;23(6):182. |
| Unit | Bottle |
| Specification | 250mg 500mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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