CAS:54-71-7
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
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Pilocarpine HydrochlorideCAS:54-71-7
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 54-71-7 |
Chinese Name | 盐酸毛果芸香碱 |
English Name | Pilocarpine Hydrochloride |
Synonyms | NSC 5746 HCl;(+)-Pilocarpine hydrochloride |
Molecular Formula | C11H17ClN2O2 |
Molecular Weight | 244.72 |
Solubility | Soluble in Water/DMSO(Need ultrasonic) |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
EC | EINECS 200-212-5 |
MDL | MFCD00012722 |
SMILES | CCC1C(COC1=O)CC2=CN=CN2C.Cl |
InChIKey | RNAICSBVACLLGM-GNAZCLTHSA-N |
InChI | InChI=1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1 |
PubChem CID | 5909 |
Target Point | mAChR |
Passage | Neuronal Signaling;GPCR & G Protein |
Background | It is an effective M3 muscarinic receptor agonist. |
Biological Activity | Pilocarpine Hydrochloride 是一种强效的 M3 毒蕈碱乙酰胆碱受体激动剂。[1-4] |
In Vitro | 盐酸毛果芸香碱通过降低平滑肌中动作电位的频率能唤起大鼠尾动脉离体段的浓度依赖性松弛,其 EC50 为 2.4 x 10(-3)M[2]。盐酸毛果芸香碱(浓度高于0.625 g/L)对 HCS 细胞具有剂量和时间依赖性细胞毒性,可诱导这些细胞凋亡;盐酸毛果芸香碱(2.5 g/L)还能诱导细胞 S 期停滞、PS 外化、MTP 破坏以及 caspase-8、-9 和-3 激活[3]。 |
In Vivo | 腹腔注射(0.5 mg-kg-1)盐酸毛果芸香碱能诱导运动大鼠唾液分泌增加[1]。在动物癫痫模型中,盐酸毛果芸香碱(25nmol/kg;静脉注射;每天一次)可以减轻慢性炎症反应,活化的小胶质细胞和星形胶质细胞数量减少,海马中 TNF-α 和 IL-1 水平降低[4]。 |
Data Literature Source | [1]. Matsuzaki K,et al. Daily voluntary exercise enhances pilocarpine-induced saliva secretion and aquaporin 1 expression in rat submandibular glands. FEBS Open Bio. 2017 Dec 7;8(1):85-93. [2]. Tonta MA,et al. Pilocarpine-induced relaxation of rat tail artery by a non-cholinergic mechanism and in the absence of an intact endothelium. Br J Pharmacol. 1994 Jun;112(2):525-32. [3]. Yuan XL,et al. Cytotoxicity of pilocarpine to human corneal stromal cells and its underlying cytotoxic mechanisms. Int J Ophthalmol. 2016 Apr 18;9(4):505-11. [4]. Wang RF,et al. Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res. 2018 May;142:45-52. |
Unit | Bottle |
Specification | 50mg 100mg |