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My CartCAS：6211-32-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 6211-32-1 |
| Name | Rauwolscine Hydrochloride |
| Molecular Formula | C21H27ClN2O3 |
| Molecular Weight | 390.9 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 228-279-6 |
| SMILES | COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O.Cl |
| InChIKey | PIPZGJSEDRMUAW-ZKKXXTDSSA-N |
| InChI | InChI=1S/C21H26N2O3.ClH/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24;/h2-5，12，15，17-19，22，24H，6-11H2，1H3;1H/t12-，15+，17+，18+，19+;/m1./s1 |
| PubChem CID | 197067 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is a highly effective, selective alpha2 adrenergic receptor antagonist. |
| Biological Activity | Rauwolscine Hydrochloride 是一种特异性强效 α2 肾上腺素能受体拮抗剂，其Ki 值为 12 nM。[1] |
| In Vitro | [3H]Rauwolscine hydrochloride specifically labels both the high and low affinity states of the alpha 2-receptor in brain membranes.[1] The alpha 2 adrenergic antagonist [3H]rauwolscine binds with comparable nanomolar affinity to alpha 2 adrenoceptors and the nonadrenergic 5-HT1A receptors sites in human frontal cortex membranes.[2] Rauwolscine was determined to have relatively high affinity for the human receptor(Ki human = 14.3+/-1.2 nM，compared to Ki rat = 35.8+/-3.8 nM). The affinity of [3H]rauwolscine for the human 5-HT2B receptor at 0 degrees C did not change，Kd = 4.93+/-1.27 nM，while that for [3H]5-HT increased greatly(Kd at 37 degrees C = 7.76+/-1.06 nM; Kd at 0 degrees C = 0.0735+/-0.0081 nM).[3] Saturation studies showed that the affinity of [3H]-rauwolscine was similar in all species(2.33-3.03 nM)except man where it was significantly higher(0.98 nM). [3H]-rauwolscine binds with low affinity(KD greater than 15 nM)to membranes prepared from guinea-pig kidney.[4] |
| Data Literature Source | [1]. Perry BD，et al. [3H]rauwolscine (alpha-yohimbine): a specific antagonist radioligand for brain alpha 2-adrenergic receptors. Eur J Pharmacol. 1981 Dec 17;76(4):461-4. [2]. De Vos H，et al. [3H]rauwolscine behaves as an agonist for the 5-HT1A receptors in human frontal cortex membranes. Eur J Pharmacol. 1991 May 25;207(1):1-8. [3]. Wainscott DB，et al. [3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn Schmiedebergs Arch Pharmacol. 1998 Jan;357(1):17-24. [4]. Neylon CB，et al. [3H]-rauwolscine binding to alpha 2-adrenoceptors in the mammalian kidney: apparent receptor heterogeneity between species. Br J Pharmacol. 1985 Jun;85(2):349-59. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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