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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > SulindacCAS：38194-50-2
Molecular Formula：C20H17FO3S
Molecular Weight：356.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 38194-50-2 |
| Name | Sulindac |
| Molecular Formula | C20H17FO3S |
| Molecular Weight | 356.41 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 253-819-2 |
| MDL | MFCD00599589 |
| SMILES | CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O |
| InChIKey | MLKXDPUZXIRXEP-MFOYZWKCSA-N |
| InChI | InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H，11H2，1-2H3，(H，22，23)/b17-9- |
| PubChem CID | 1548887 |
| Target Point | COX |
| Passage | Immunology & Inflammation |
| Background | It is a nonsteroidal COX inhibitor and an immunomodulator. |
| Biological Activity | Sulindac 是一种口服活性非甾体抗炎药，也是一种免疫调节剂，可用于研究癌症，包括结肠直肠癌（CRC）和肺癌。[1-2] |
| Data Literature Source | [1]. Cha BK，et al. Celecoxib and sulindac inhibit TGF-β1-induced epithelial-mesenchymal transition and suppress lung cancer migration and invasion via downregulation of sirtuin 1. Oncotarget. 2016 Aug 30;7(35):57213-57227. [2]. Yi B，et al. Sulindac Modulates the Response of Proficient MMR Colorectal Cancer to Anti-PD-L1 Immunotherapy. Mol Cancer Ther. 2021 Jul;20(7):1295-1304. |
| Unit | Bottle |
| Specification | 50mg 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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