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My CartCAS：5985-28-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 5985-28-4 |
| Name | Synephrine Hydrochloride |
| Molecular Formula | C9H14ClNO2 |
| Molecular Weight | 203.67 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 227-804-6 |
| MDL | MFCD00050566 |
| SMILES | CNCC(C1=CC=C(C=C1)O)O.Cl |
| InChIKey | COTCEGYSNTWJQV-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H13NO2.ClH/c1-10-6-9(12)7-2-4-8(11)5-3-7;/h2-5，9-12H，6H2，1H3;1H |
| PubChem CID | 42609626 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is an alpha-Adrenergic and β-adrenergic agonist. |
| Biological Activity | Synephrine Hydrochloride 是一种生物碱，是从酸橙中提取的一种α肾上腺素能和β肾上腺素能激动剂。[1-3] |
| In Vitro | 哌唑嗪、BRL15572 和酮塞林能显著抑制辛弗林盐酸盐(1 x 10(-7)- 3 x 10(-5)mol/L)对血管的收缩作用。辛弗林盐酸盐的收缩通过肾上腺素能α(1)受体和血清素能(5-HT(1D)和 5-HT(2A))受体发挥作用[2]。 |
| In Vivo | 通过灌胃给门静脉结扎(PVL)和胆管结扎(BDL)大鼠连续注射 8 天辛弗林盐酸盐，可在两种门静脉高压大鼠模型中发挥有益的血流动力学效应[1]。 |
| Data Literature Source | [1]. Huang YT，et al. Hemodynamic effects of synephrine treatment in portal hypertensive rats. Jpn J Pharmacol. 2001 Feb;85(2):183-8. [2]. Hibino T，et al. synephrine，a component of Evodiae Fructus，constricts isolated rat aorta via adrenergic and serotonergic receptors. J Pharmacol Sci. 2009 Sep;111(1):73-81. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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