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My CartCAS：64887-14-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 64887-14-5 |
| Name | Urapidil Hydrochloride |
| Molecular Formula | C20H30ClN5O3 |
| Molecular Weight | 423.94 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 636-348-0 |
| MDL | MFCD00078601 |
| SMILES | CN1C(=CC(=O)N(C1=O)C)NCCCN2CCN(CC2)C3=CC=CC=C3OC.Cl |
| InChIKey | KTMLZVUAXJERAT-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H29N5O3.ClH/c1-22-18(15-19(26)23(2)20(22)27)21-9-6-10-24-11-13-25(14-12-24)16-7-4-5-8-17(16)28-3;/h4-5，7-8，15，21H，6，9-14H2，1-3H3;1H |
| PubChem CID | 167980 |
| Target Point | Adrenergic Receptor;5-HT Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is an α1-adrenergic receptor antagonist and a 5-HT1A receptor agonist with antihypertensive activity. |
| Biological Activity | Urapidil Hydrochloride 是一种口服活性α1-肾上腺素受体拮抗剂和 5-HT1A 受体激动剂，对α1-和α2-肾上腺素受体的 pIC50 分别为 6.13 和 4.38，具有降压作用。[1-2] |
| In Vitro | Urapidil and its analogues produced half-maximum inhibition of 3H-8-OH-DPAT binding at concentrations of 4 x 10(-9)mol/l to 4 x 10(-7)mol/l with the following order of potency. The IC50 values of urapidil and its derivatives for 3H-prazosin binding were in the range of 5 x 10(-8)mol/l to 8 x 10(-7)mol/l.[1] |
| Data Literature Source | [1]. Gross G，et al. Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for alpha 1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch Pharmacol. 1987 Dec;336(6):597-601. [2]. Buch J. Urapidil，a dual-acting antihypertensive agent: Current usage considerations. Adv Ther. 2010 Jul;27(7):426-43. |
| Unit | Bottle |
| Specification | 50mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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