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My CartCAS：503070-58-4
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 503070-58-4 |
| Name | Vilanterol Trifenate |
| Molecular Formula | C44H49Cl2NO7 |
| Molecular Weight | 774.77 |
| Solubility | Soluble in DMSO ≥10mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C(=O)O.C1=CC(=C(C(=C1)Cl)COCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O)Cl |
| InChIKey | KLOLZALDXGTNQE-JIDHJSLPSA-N |
| InChI | InChI=1S/C24H33Cl2NO5.C20H16O2/c25-21-6-5-7-22(26)20(21)17-32-13-12-31-11-4-2-1-3-10-27-15-24(30)18-8-9-23(29)19(14-18)16-28;21-19(22)20(16-10-4-1-5-11-16，17-12-6-2-7-13-17)18-14-8-3-9-15-18/h5-9，14，24，27-30H，1-4，10-13，15-17H2;1-15H，(H，21，22)/t24-;/m0./s1 |
| PubChem CID | 44482554 |
| Target Point | Adrenergic Receptor |
| Passage | Endocrinology & Hormones;GPCR & G Protein；Neuronal Signaling |
| Background | It is a long-acting β2-AR agonist. |
| Biological Activity | Vilanterol Trifenate 是一种长效β2-肾上腺素受体（β2-AR）激动剂，具有 24 小时固有活性，对 β2-AR、β1-AR 和 β3-AR 的 pEC50 分别为 10.37、6.98 和 7.36。[1-2] |
| In Vitro | Vilanterol trifenatate(vilanterol)displayed a subnanomolar affinity for the β(2)-AR，vilanterol demonstrated similar selectivity as salmeterol for β(2)- over β(1)-AR and β(3)-AR.[1] |
| In Vivo | In human airways，vilanterol was shown to have a faster onset and longer duration of action than salmeterol，exhibiting a significant level of bronchodilation 22 h after treatment.[1] Vilanterol(VI; 25-100 μg; once daily，14 days)was well tolerated asthma and COPD，and produced a rapid and prolonged bronchodilation over 24 h.[2] |
| Data Literature Source | [1]. Slack RJ，et al. In vitro pharmacological characterization of vilanterol，a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action. J Pharmacol Exp Ther. 2013 Jan;344(1):218-30. [2]. Kempsford R，et al. Vilanterol trifenatate，a novel inhaled long-acting beta2 adrenoceptor agonist，is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther. 2013 Apr;26(2):256-64. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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