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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > cGAMPCAS：849214-04-6
Molecular Formula：C20H24N10O13P2
Molecular Weight：674.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to yellow Solid
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| CAS | 849214-04-6 |
| Name | cGAMP |
| Molecular Formula | C20H24N10O13P2 |
| Molecular Weight | 674.41 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)O)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)O)O |
| InChIKey | RFCBNSCSPXMEBK-INFSMZHSSA-N |
| InChI | InChI=1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-10(31)12-6(40-18)1-38-45(36，37)43-13-7(2-39-44(34，35)42-12)41-19(11(13)32)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7，10-13，18-19，31-32H，1-2H2，(H，34，35)(H，36，37)(H2，21，23，24)(H3，22，27，28，33)/t6-，7-，10-，11-，12-，13-，18-，19-/m1/s1 |
| PubChem CID | 135471108 |
| Target Point | STING |
| Passage | Immunology & Inflammation |
| Background | cGAMP acts as an endogenous second messenger and triggers the production of interferon in response to cytoplasmic DNA. cGAMP activates interferon gene stimulator (STING), which activates the signaling cascade that leads to the production of type I interferon and other immune mediators. |
| Biological Activity | cGAMP 是元类动物体内的一种内源性第二信使，可触发细胞 DNA 产生干扰素。[1-4] |
| Data Literature Source | [1]. Wu J，et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30. [2]. krnjug I，et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150. doi: 10.1371/journal.pone.0110150. Erratum in: PLoS One. 2015;10(3):e0123605. Ruecker，Christine [corrected to Rueckert，Christine]. [3]. Liu Y，et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-518. [4]. Ablasser A，Schmid-Burgk JL，Hemmerling I，Horvath GL，Schmidt T，Latz E，Hornung V. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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