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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > Ambroxol HydrochlorideCAS：23828-92-4
Molecular Formula：C13H19Br2ClN2O
Molecular Weight：414.56
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 23828-92-4 |
| Name | Ambroxol Hydrochloride |
| Molecular Formula | C13H19Br2ClN2O |
| Molecular Weight | 414.56 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-899-2 |
| MDL | MFCD00078932 |
| Target Point | GCase |
| Passage | Metabolic Enzyme&Protease |
| Background | It is a glucosinolidase (GCase) chaperone that increases the activity of glucosinolidase. |
| Biological Activity | Ambroxol Hydrochloride 是前体溴己辛的活性代谢产物，是一种葡糖脑苷脂酶 (GCase) 伴侣，可增加葡糖脑苷脂酶的活性，也是有效的神经性钠离子通道抑制剂，抑制抗TTX的钠离子电流，相位性阻滞，IC50为22.5 μM，抑制对TTX敏感的钠离子电流，IC50为100 μM。[1-3] |
| Data Literature Source | [1]. Migdalska-Richards A，et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775. [2]. Weiser T，Wilson N. Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. Mol Pharmacol. 2002 Sep;62(3):433-8. [3]. Gibbs BF，Schmutzler W，Vollrath IB，Brosthardt P，Braam U，Wolff HH，Zwadlo-Klarwasser G. Ambroxol inhibits the release of histamine，leukotrienes and cytokines from human leukocytes and mast cells. Inflamm Res. 1999 Feb;48(2):86-93. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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