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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > GPCR & G Protein > NKH477CAS：138605-00-2
Molecular Formula：C27H44ClNO8
Molecular Weight：546.09
Storage：Powder:2-8℃，2 years
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 138605-00-2 |
| Name | NKH477 |
| Molecular Formula | C27H44ClNO8 |
| Molecular Weight | 546.09 |
| Solubility | Soluble in Water/DMSO(Need ultrasonic)(This product is not stable in solution, it is recommended that you use it now) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years |
| SMILES | CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)OC(=O)CCN(C)C.Cl |
| InChIKey | VIRRLEDAYYYTOD-YHEOSNBFSA-N |
| InChI | InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3，4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27，7)36-24;/h10，17，20-22，30，33H，1，11-15H2，2-9H3;1H/t17-，20-，21-，22-，24-，25-，26+，27-;/m0./s1 |
| PubChem CID | 444028 |
| Target Point | Adenylate Cyclase |
| Passage | GPCR & G Protein |
| Background | NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. |
| Biological Activity | NKH477 可直接激活腺苷酸环化酶的催化单元并增加细胞内的 cAMP。NKH477 是一种毛喉素衍生物，通过对心脏舒张功能的有益影响来改善心力衰竭。NKH477 通在大鼠体内对细胞有抗增殖作用，从而抑制大鼠异位肺移植的急性排斥反应。[1] |
| Data Literature Source | [1]. Nakashima S，et al. Antiproliferative effects of NKH477，a forskolin derivative，on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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