CAS:1227301-51-0
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
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Philanthotoxin 74 DihydrochlorideCAS:1227301-51-0
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 1227301-51-0 |
Chinese Name | Philanthotoxin 74二盐酸盐 |
English Name | Philanthotoxin 74 Dihydrochloride |
Synonyms | PhTx74dihydrochloride |
Molecular Formula | C24H44Cl2N4O3 |
Molecular Weight | 507.54 |
Solubility | Soluble in Water/DMSO(Need ultrasonic) |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
SMILES | CCCC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)NCCCCCCCNCCCCN.Cl.Cl |
InChIKey | HWTJQQMIKVJWLH-IKXQUJFKSA-N |
InChI | InChI=1S/C24H42N4O3.2ClH/c1-2-10-23(30)28-22(19-20-11-13-21(29)14-12-20)24(31)27-18-8-5-3-4-7-16-26-17-9-6-15-25;;/h11-14,22,26,29H,2-10,15-19,25H2,1H3,(H,27,31)(H,28,30);2*1H/t22-;;/m0../s1 |
PubChem CID | 46213501 |
Target Point | iGluR |
Passage | Membrane Transporter&Ion Channel |
Background | It is an antagonist to AMPAR. |
Biological Activity | Philanthotoxin 74 dihydrochloride 是一种 AMPAR 拮抗剂,抑制 GluR3 和 GluR1 的 IC50 分别为 263 和 296 nM。[1] |
IC50 | GluR1: 296nM(IC50)[1] |
In Vitro | Philanthotoxin 74 Dihydrochloride(PhTX-74)inhibits homomeric GluA1 and GluA3 receptors nonselectively,with IC(50)values in the nanomolar range(252-356 nM),and heteromeric GluA1/A2 and GluA2/A3 receptors nonselectively,with IC(50)values in the micromolar range(22 μM). PhTX-74 cannot pharmacologically discriminate between GluA2-containing AMPAR subtypes.[1] |
Data Literature Source | [1]. Poulsen MH,et al. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Mol Pharmacol. 2014 Feb;85(2):261-8. |
Unit | Bottle |
Specification | 1mg |