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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > ML365CAS：947914-18-3
Molecular Formula：C22H20N2O3
Molecular Weight：360.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 947914-18-3 |
| Name | ML365 |
| Molecular Formula | C22H20N2O3 |
| Molecular Weight | 360.41 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC1=CC(=CC=C1)C(=O)NC2=CC(=CC=C2)NC(=O)C3=CC=CC=C3OC |
| InChIKey | UTAJHKSGYJSZBR-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H，1-2H3，(H，23，25)(H，24，26) |
| PubChem CID | 46785920 |
| Target Point | Potassium Channel (TASK1/KCNK3) |
| Passage | Membrane Transporter&Ion Channel |
| Background | ML365 is a selective 2-pore domain potassium channel TASK1/KCNK3 inhibitor. |
| Biological Activity | ML365 是 TASK1/KCNK3 的双孔域钾通道抑制剂，可作为探针，用于检查 TASK1 通道的特定作用。[1] |
| IC50 | TASK1/KCNK3: 4nM(IC50);TASK3/KCNK9: 390nM(IC50) [1] |
| Data Literature Source | [1]. Zou B，et al. ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel. 2013 Apr 15 [updated 2013 Nov 14] |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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