CAS:104632-26-0
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
Array ( [133] => Array ( [id] => 133 [name] => Inhibitors & Antagonists & Agonists [num] => 3416 [children] => Array ( [352] => Array ( [id] => 352 [name] => Protein Tyrosine Kinase/PTK ) [350] => Array ( [id] => 350 [name] => PI3K/Akt/mTOR ) [351] => Array ( [id] => 351 [name] => Endocrinology & Hormones ) [357] => Array ( [id] => 357 [name] => Angiogenesis ) [358] => Array ( [id] => 358 [name] => HIF ) [363] => Array ( [id] => 363 [name] => Immunology & Inflammation ) [364] => Array ( [id] => 364 [name] => Stem Cells ) [365] => Array ( [id] => 365 [name] => Apoptosis ) [377] => Array ( [id] => 377 [name] => Metabolic Enzyme & Protease ) [379] => Array ( [id] => 379 [name] => Autophagy ) [380] => Array ( [id] => 380 [name] => ER Stress ) [384] => Array ( [id] => 384 [name] => Cell Cycle ) [385] => Array ( [id] => 385 [name] => Cytoskeleton ) [386] => Array ( [id] => 386 [name] => DNA Damage & DNA Repai ) [387] => Array ( [id] => 387 [name] => Epigenetics ) [388] => Array ( [id] => 388 [name] => Ubiquitin ) [389] => Array ( [id] => 389 [name] => JAK/STAT ) [390] => Array ( [id] => 390 [name] => GPCR & G Protein ) [391] => Array ( [id] => 391 [name] => Neuronal Signal Pathway ) [392] => Array ( [id] => 392 [name] => MAPK ) [393] => Array ( [id] => 393 [name] => NF-κB ) [394] => Array ( [id] => 394 [name] => Membrane Transporter & Ion Channel ) [395] => Array ( [id] => 395 [name] => TGF-β/Smad ) [396] => Array ( [id] => 396 [name] => Hippo ) [775] => Array ( [id] => 775 [name] => Antibody-drug Conjugate/ADC Related ) [122] => Array ( [id] => 122 [name] => Others ) ) ) )
>
Small Molecule Compounds >
Inhibitors & Antagonists & Agonists >
Neuronal Signal Pathway >
PramipexoleCAS:104632-26-0
Storage:Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:White to off-white Solid
CAS | 104632-26-0 |
Chinese Name | 普拉克索 |
English Name | Pramipexole |
Synonyms | 普拉克索;Valaciclovir;普拉克索 |
Molecular Formula | C10H17N3S |
Molecular Weight | 211.33 |
Solubility | Soluble in DMSO(Need ultrasonic) |
Purity | ≥98% |
Appearance | White to off-white Solid |
Storage | Powder:-20℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
MDL | MFCD00869076 |
SMILES | CCCN[C@H]1CCC2=C(C1)SC(=N2)N |
InChIKey | FASDKYOPVNHBLU-ZETCQYMHSA-N |
InChI | InChI=1S/C10H17N3S/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8/h7,12H,2-6H2,1H3,(H2,11,13)/t7-/m0/s1 |
PubChem CID | 119570 |
Target Point | Dopamine Receptor |
Passage | Neuronal Signaling;GPCR & G Protein |
Background | It is a selective, blood-brain barrier (BBB) -permeable D2-type dopamine receptor agonist that can be used in studies related to Parkinsons disease and leg hyperactivity syndrome. |
Biological Activity | Pramipexole 是一种具有选择性和血脑屏障(BBB)穿透性的多巴胺 D2 型受体激动剂,可用于帕金森病(PD)和不宁腿综合征(RLS)的研究。[1-4] |
In Vitro | Pramipexole dhydrochloride hydrate is in part transported across the BBB by an organic cation-sensitive transporter. The pramipexole transport in RBEC1 was pH-dependent,but sodium- and membrane potential-independent.[1] Pramipexole dhydrochloride hydrate(0.01-10 μM; 72 hours; hiPSCs)produced dose-dependent increases of dendritic arborization and soma size.[2] Pramipexole dhydrochloride hydrate reduced levodopa-induced THir cell loss in a dose-dependent and saturable fashion(ED50 = 500 pM).[3] |
In Vivo | Pramipexole dhydrochloride hydrate(0.25 mg and 1 mg/kg body weight)induces the neurological recovery through mitochondrial pathways in ischemia/reperfusion injury.[4] |
Animal Experiment | Male Wistar rats underwent transient middle cerebral artery occlusion(tMCAO)and then received pramipexole(0.25 mg and 1 mg/kg body weight)at 1,6,12 and 18 h post-occlusion.[4] |
Data Literature Source | [1]. Okura T,et al. Blood-brain barrier transport of pramipexole,a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71. [2]. Collo G,et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018 Feb 4;2018:4196961. [3]. Carvey PM,et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28. [4]. Andrabi SS,er al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 29;12(8):dmm033860. |
Unit | Bottle |
Specification | 100mg |