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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > PalbociclibCAS：571190-30-2
Molecular Formula：C24H29N7O2
Molecular Weight：447.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 571190-30-2 |
| Name | Palbociclib |
| Molecular Formula | C24H29N7O2 |
| Molecular Weight | 447.53 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11840850 |
| SMILES | CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCNCC4)C5CCCC5)C(=O)C |
| InChIKey | AHJRHEGDXFFMBM-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8，13-14，17，25H，3-6，9-12H2，1-2H3，(H，26，27，28，29) |
| PubChem CID | 5330286 |
| Target Point | CDK |
| Passage | Cell Cycle |
| Background | It is an orally active selective inhibitor of CDK4 and CDK6, which has anti-proliferative activity on cancer cells and induces cell cycle arrest. It can be used in HR-positive and HER2-negative breast cancer, as well as related studies of hepatocellular carcinoma. |
| Biological Activity | Palbociclib 是一种口服活性选择性 CDK4 和 CDK6 抑制剂，IC50 值分别为 11 和 16 nM。Palbociclib 具有很强的抗增殖活性，能诱导癌细胞的细胞周期停滞，可用于 HR 阳性和 HER2 阴性乳腺癌和肝细胞癌的研究。[1-3] |
| IC50 | Cdk4/cyclin D3: 9nM(IC50);Cdk4/cyclin D1: 11nM(IC50);Cdk6/cyclin D2: 16nM(IC50) [1] |
| Data Literature Source | [1]. Fry DW，et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38. [2]. Finn RS，et al. PD 0332991，a selective cyclin D kinase 4/6 inhibitor，preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro. Breast Cancer Res. 2009;11(5):R77. [3]. Bollard J，et al. Palbociclib (PD-0332991)，a selective CDK4/6 inhibitor，restricts tumour growth in preclinical models of hepatocellular carcinoma. Gut. 2017 Jul;66(7):1286-1296. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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