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My Cart> Small Molecule Compounds > Anti-Infection > Antibiotic > Pirarubicin HydrochlorideCAS：95343-20-7
Molecular Formula：C32H38ClNO12
Molecular Weight：664.1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 95343-20-7 |
| Name | Pirarubicin Hydrochloride |
| Molecular Formula | C32H38ClNO12 |
| Molecular Weight | 664.1 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)OC6CCCCO6.Cl |
| InChIKey | ZPHYPKKFSHAVOE-YZIXBPQXSA-N |
| InChI | InChI=1S/C32H37NO12.ClH/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40，20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38;/h5-7，14，17，19，21-22，31，34，37，39-40H，3-4，8-13，33H2，1-2H3;1H/t14-，17-，19-，21+，22-，31+，32-;/m0./s1 |
| PubChem CID | 20846247 |
| Target Point | Antibiotic;Topoisomerase |
| Passage | Anti-infection |
| Background | It is an anthracycline antibiotic and an inhibitor of topoisomerase II, which can be used in related studies of various cancers, especially solid tumors. |
| Biological Activity | Pirarubicin Hydrochloride 是一种蒽环类抗生素，一种拓扑异构酶 II 抑制剂，被广泛用于各种癌症，尤其是实体瘤的治疗。[1-4] |
| Data Literature Source | [1]. Takigawa N，et al. [Cytotoxic effect of topoisomerase II inhibitors against adriamycin- and etoposide-resistant small cell lung cancer sublines]. Gan To Kagaku Ryoho. 1993 May;20(7):929-35. [2]. Nagai K，et al. Relationships between the in vitro cytotoxicity and transport characteristics of pirarubicin and doxorubicin in M5076 ovarian sarcoma cells，and comparison with those in Ehrlich ascites carcinoma cells. Cancer Chemother Pharmacol. 2002 Mar;49(3):244-50. [3]. Li K，et al. Pirarubicin induces an autophagic cytoprotective response through suppression of the mammalian target of rapamycin signaling pathway in human bladder cancer cells. Biochem Biophys Res Commun. 2015 May 1;460(2):380-5. [4]. Wang YD，et al. Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. J Asian Nat Prod Res. 2018 Apr;20(4):361-373. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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