Phenacetin

The antipyretic and analgesic effects of phenacetin are similar to those of acetylsalicylic acid. Phenacetin is mainly used as an antipyretic and analgesic drug. It has a slow and lasting effect on headache, neuralgia, arthralgia and fever, but its antirheumatic and anti-inflammatory effects are weak. Methemoglobin overdose can cause disease, result from a lack of oxygen to the body, long-term use can damage the kidneys and even cause nipple necrosis, should be careful. Due to its toxic side effects and the rapid development of other drugs in the same class, the drug has been discontinued as a single drug, only as a raw material and other drugs in compound preparations. It is often combined with aspirin and caffeine to form a compound aspirin. Its composition is phenacetin 0.162 g, aspirin 0.227 g and caffeine 0.035 g. It has less toxicity and is used for the treatment of cold and cold. If a small amount of pheniramine is added to the above drugs, pheniramine cold tablets can also be made, which can be used to treat cold, headache, neuralgia, rheumatic pain, etc.

Phenacetin itself no antipyretic analgesic effect, inside the body, after metabolism decomposition that acetaminophen paracetamol, namely an antipyretic analgesic effect. Para-aminophenyl ether was also decomposed. Para-aminophenyl ether not only had no antipyretic and analgesic effect, but also was the main factor of the toxic side effects of phenacetin.

China began to produce phenacetin in 1954. It was prepared by etherization of nitrochlorobenzene and ethanol to p-nitrophenyl ether, which was then reduced to p-aminophenyl ether and acetylated with acetic acid.

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Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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