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KRM-III

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Cat.No：IK0610 Solarbio

CAS：79220-94-3

Molecular Formula：C₁₅H₁₂N₂S

Molecular Weight：252.33

Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year

Purity：≥98%

Appearance：Light yellow to yellow Solid

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Product Information

CAS	79220-94-3
Name	KRM-III
Molecular Formula	C₁₅H₁₂N₂S
Molecular Weight	252.33
Solubility	Soluble in DMSO
Purity	≥98%
Appearance	Light yellow to yellow Solid
Storage	Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
SMILES	C1=CC=C(C=C1)C2=CN(C(=S)N2)C3=CC=CC=C3
InChIKey	QKOAQVKXZJFMET-UHFFFAOYSA-N
InChI	InChI=1S/C15H12N2S/c18-15-16-14(12-7-3-1-4-8-12)11-17(15)13-9-5-2-6-10-13/h1-11H，(H，16，18)
PubChem CID	736689
Target Point	TCR;NFAT
Passage	Immunology&Inflammation
Background	KRM-III is a potent T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR-induced NFAT nuclear factor activation and T cell proliferation.
Biological Activity	KRM-III 是一种口服活性 T 细胞抗原受体（TCR）抑制剂，抑制 TCR 和佛波醇肉豆蔻酸酯醋酸酯/离子霉素诱导的 T 细胞核因子（NFAT）的活化和 T 细胞增殖，IC50 为 ~5 μM。[1]
Data Literature Source	[1]. Jung EJ，et al. Oral administration of 1，4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13.
Unit	Bottle
Specification	5mg

Remark：These protocols are for reference only. Solarbio does not independently validate these methods.

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