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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Others > CADD522CAS：199735-88-1
Molecular Formula：C15H13Cl2NO3
Molecular Weight：326.17
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 199735-88-1 |
| Name | CADD522 |
| Molecular Formula | C15H13Cl2NO3 |
| Molecular Weight | 326.17 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00167693 |
| SMILES | C1C2C=CC1C(C2C(=O)NC3=CC(=C(C=C3)Cl)Cl)C(=O)O |
| InChIKey | YSDNWNOGHQYWPK-UHFFFAOYSA-N |
| InChI | InChI=1S/C15H13Cl2NO3/c16-10-4-3-9(6-11(10)17)18-14(19)12-7-1-2-8(5-7)13(12)15(20)21/h1-4，6-8，12-13H，5H2，(H，18，19)(H，20，21) |
| PubChem CID | 2834870 |
| Target Point | RUNX2-DNA binding |
| Passage | Others |
| Background | It is a RUNX2-DNA binding inhibitor that can be used in cancer research. |
| Biological Activity | CADD522 是一种 RUNX2 DNA 结合抑制剂，IC50 为 10 nM。CADD522 可用于癌症研究，可通过增加线粒体驱动的细胞 ROS 水平发挥抗肿瘤活性。[1-2] |
| IC50 | RUNX2: 10nM(IC50) [1] |
| Data Literature Source | [1]. Kim MS，et al. Characterization of CADD522，a small molecule that inhibits RUNX2-DNA binding and exhibits antitumor activity. Oncotarget. 2017 Aug 10;8(41):70916-70940. [2]. Kim MS，et al. Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis. Oncotarget. 2020 Oct 27;11(43):3863-3885. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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