CAS:1428-95-1
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Light yellow to yellow Solid
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5-(N,N-Hexamethylene)-amilorideCAS:1428-95-1
Storage:Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year
Purity:≥98%
Appearance:Light yellow to yellow Solid
CAS | 1428-95-1 |
Chinese Name | 5-(N,N-六亚甲基)阿米洛利 |
English Name | 5-(N,N-Hexamethylene)-amiloride |
Synonyms | Hexamethyleneamiloride |
Molecular Formula | C12H18ClN7O |
Molecular Weight | 311.77 |
Solubility | Soluble in DMSO |
Purity | ≥98% |
Appearance | Light yellow to yellow Solid |
Storage | Powder:2-8℃,2 years;Insolvent(Mother Liquid):-20℃,6 months;-80℃,1 year |
SMILES | C1CCCN(CC1)C2=NC(=C(N=C2Cl)C(=O)N=C(N)N)N |
InChIKey | RQQJJXVETXFINY-UHFFFAOYSA-N |
InChI | InChI=1S/C12H18ClN7O/c13-8-10(20-5-3-1-2-4-6-20)18-9(14)7(17-8)11(21)19-12(15)16/h1-6H2,(H2,14,18)(H4,15,16,19,21) |
PubChem CID | 1794 |
Target Point | Na+/H+ exchanger;HIV |
Passage | Membrane Transporter&Ion Channel |
Background | It is an effective Na+/H+ exchange inhibitor and also an ion channel inhibitor of HIV-1 Vpu virus. |
Biological Activity | 5-(N,N-Hexamethylene)-amiloride 是一种 Na+/H+ 交换抑制剂,一种 HIV-1 Vpu 病毒离子通道的抑制剂,可抑制小鼠肝炎病毒 (MHV) 复制和人冠状病毒 229E (HCoV229E) 在培养的 L929 细胞中的复制,其 EC50 分别为 3.91 μM 和 1.34 μM。[1-2] |
In Vitro | 5-(N,N-Hexamethylene)-amiloride,a Na(+)/H(+)exchanger inhibitor,decreases the pH(i)and induces apoptosis.[1] 5-(N,N-Hexamethylene)-amiloride,an inhibitor of the HIV-1 Vpu virus ion channel,inhibited the HCoV-229E and MHV E protein ion channel conductance in bilayers and also inhibited replication of the parent coronaviruses in cultured cells.[2] |
Data Literature Source | [1]. Rich IN,et al. Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood. 2000 Feb 15;95(4):1427-34. [2]. Wilson L,et al. Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology. 2006 Sep 30;353(2):294-306. |
Unit | Bottle |
Specification | 5mg |