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My CartCAS：2377151-10-3
Molecular Formula：C25H23F3N4O4S
Molecular Weight：532.53
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2377151-10-3 |
| Name | ZL0580 |
| Molecular Formula | C25H23F3N4O4S |
| Molecular Weight | 532.53 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | C1CC(N(C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)NC3=CC=C(C=C3)C(F)(F)F)C(=O)NC4=CC=CC=C4 |
| InChIKey | DKFYGSWCJGXEJY-QFIPXVFZSA-N |
| InChI | InChI=1S/C25H23F3N4O4S/c26-25(27，28)17-8-10-19(11-9-17)30-24(34)31-20-12-14-21(15-13-20)37(35，36)32-16-4-7-22(32)23(33)29-18-5-2-1-3-6-18/h1-3，5-6，8-15，22H，4，7，16H2，(H，29，33)(H2，30，31，34)/t22-/m0/s1 |
| PubChem CID | 139524511 |
| Target Point | HIV(Tat) |
| Passage | Anti-infection |
| Background | ZL0580 inhibits HIV by selectively binding to the BRD4 domain of BD1. ZL0580 inhibits HIV by inhibiting Tat transcriptional activation and elongation and by inducing inhibitory chromatin structures on HIV promoters. |
| Biological Activity | ZL0580 通过选择性地与 BRD4 的 BD1 结构域结合，诱导对 HIV 的表观遗传抑制。ZL0580 通过抑制 Tat 的转录激活和转录延伸以及诱导 HIV 启动子的抑制性染色质结构来诱导抑制 HIV。[1] |
| Data Literature Source | [1]. Niu Q，et al. Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV. J Clin Invest. 2019 Jul 22;129(8):3361-3373. |
| Unit | Bottle |
| Specification | 2mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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