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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > 5,7-DihydroxychromoneCAS：31721-94-5
Molecular Formula：C9H6O4
Molecular Weight：178.14
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：HPLC≥98%
Appearance：White to off-white Solid
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| CAS | 31721-94-5 |
| Name | 5,7-Dihydroxychromone |
| Molecular Formula | C9H6O4 |
| Molecular Weight | 178.14 |
| Solubility | Soluble in DMSO |
| Purity | HPLC≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD14583153 |
| SMILES | C1=COC2=CC(=CC(=C2C1=O)O)O |
| InChIKey | NYCXYKOXLNBYID-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H6O4/c10-5-3-7(12)9-6(11)1-2-13-8(9)4-5/h1-4，10，12H |
| PubChem CID | 5281343 |
| Target Point | Nrf2;PPARγ;LXRα |
| Passage | NF-κB;Cell Cycle;DNA Damage/DNA Repair;Metabolic Enzyme&Protease |
| Background | 5,7-Dihydroxychromone is an effective activator of Nrf2/ARE signals. It is also a potent activator of PPARγ and LXRα with antioxidant activity. |
| Biological Activity | 5，7-Dihydroxychromone 是一种天然抗氧化剂，是 Nrf2/ARE 信号的激活剂，也是 PPARγ 和 LXRα 的激活剂。5，7-Dihydroxychromone 可抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的 caspase-3 和 caspase-9 以及裂解的 PARP 的表达。[1-2] |
| Data Literature Source | [1]. Koo HJ，et al. Anti-diabetic properties of Daphniphyllum macropodum fruit and its active compound. Biosci Biotechnol Biochem. 2014;78(8):1392-401. [2]. Kim DW，et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5，7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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