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My CartCAS：1393-48-2
Molecular Formula：C72H85N19O18S5
Molecular Weight：1664.89
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1393-48-2 |
| Name | Thiostrepton |
| Molecular Formula | C72H85N19O18S5 |
| Molecular Weight | 1664.89 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 215-734-9 |
| MDL | MFCD00135828 |
| SMILES | CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C/C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C |
| InChIKey | NSFFHOGKXHRQEW-BXVAPQLOSA-N |
| InChI | InChI=1S/C72H85N19O18S5/c1-14-26(3)47-63(105)78-30(7)57(99)75-28(5)56(98)76-31(8)58(100)91-72-19-18-40(66-85-43(22-111-66)59(101)77-29(6)55(97)74-27(4)54(73)96)81-52(72)42-21-112-67(83-42)49(34(11)109-69(107)41-20-37(32(9)92)36-16-17-39(79-47)51(95)50(36)80-41)89-60(102)44-24-113-68(86-44)53(71(13，108)35(12)94)90-62(104)45-23-110-65(84-45)38(15-2)82-64(106)48(33(10)93)88-61(103)46-25-114-70(72)87-46/h15-17，20-22，24-26，30-35，39，45，47-49，51-53，79，92-95，108H，4-6，14，18-19，23H2，1-3，7-13H3，(H2，73，96)(H，74，97)(H，75，99)(H，76，98)(H，77，101)(H，78，105)(H，82，106)(H，88，103)(H，89，102)(H，90，104)(H，91，100)/b38-15- |
| PubChem CID | 16220061 |
| Target Point | Antibiotic;FOXM1 |
| Passage | Anti-infection |
| Background | It is an antibiotic that selectively inhibits FOXM1. |
| Biological Activity | Thiostrepton 是一种天然环状低聚肽抗生素，可选择性抑制 FOXM1。[1-2] |
| Data Literature Source | [1]. Zhang X，et al. Targeting of mutant p53-induced FoxM1 with thiostrepton induces cytotoxicity and enhances carboplatin sensitivity in cancer cells. Oncotarget. 2014 Nov 30;5(22):11365-80. [2]. Sengupta A，et al. The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing's sarcoma. Int J Oncol. 2013 Sep;43(3):803-12. |
| Unit | Bottle |
| Specification | 25mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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