English Name |
Anti-PFKFB3 Polyclonal Antibody |
Chinese Name |
6-磷酸果糖-2-激酶/果糖-2, 6-二磷酸酶3抗体 |
Target |
PFKFB3 |
Synonym |
6 phosphofructo 2 kinase/ fructose 2,6 bisphosphatase; 6 phosphofructo 2 kinase/fructose 2,6 biphosphatase 3; 6-bisphosphatase; 6-P2ase 3; 6-P2ASE brain/placenta-type isozyme; 6PF 2 K/Fru 2,6 P2ASE brain/placenta type isozyme; 6PF 2-K/Fru 2,6 P2ase 3; 6PF-2-K/Fru-2; F263_HUMAN; fructose 6 phosphate,2 kinase/fructose 2, 6 bisphosphatase; Fructose-2; Inducible 6 phosphofructo 2 kinase/fructose 2,6 bisphosphatase; iPFK 2; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY REN 56; Renal carcinoma antigen NY-REN-56; uPFK 2; |
Backgroud |
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Swiss Prot |
Q16875 |
Gene ID |
5209 |
Subcellular Localization |
Cytoplasm |
Host |
Rabbit |
Clone Type |
Polyclonal Antibody |
Subtype |
IgG |
Predicted Cross-Reactivity |
Bovine;Gorilla |
Protein MW |
57/59/60/61kDa |
Observed MW |
57/62kDa |
Dilution Ratio |
WB 1:2000-5000. IHC 1:25-100. |
Immunogen |
Recombinant protein of human PFKFB3 |
Public Immunogen Range |
170-520aa |
Purification Method |
Octanoic acid-ammonium sulfate precipitation |
Storage Buffer |
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
Storage |
Store at -20℃. Avoid freeze / thaw cycles. |
Unit |
Piece |
Cross-Reactivity |
Human;Mouse;Rat |
Application |
WB;IHC |
Specification |
50ul 100ul |