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My CartCAS：1092970-12-1
Molecular Formula：C21H22BrFN4O3S
Molecular Weight：509.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1092970-12-1 |
| Name | Morphothiadin |
| Molecular Formula | C21H22BrFN4O3S |
| Molecular Weight | 509.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | CCOC(=O)C1=C(NC(=NC1C2=C(C=C(C=C2)F)Br)C3=NC=CS3)CN4CCOCC4 |
| InChIKey | SQGRDKSRFFUBBU-UHFFFAOYSA-N |
| InChI | InChI=1S/C21H22BrFN4O3S/c1-2-30-21(28)17-16(12-27-6-8-29-9-7-27)25-19(20-24-5-10-31-20)26-18(17)14-4-3-13(23)11-15(14)22/h3-5，10-11，18H，2，6-9，12H2，1H3，(H，25，26) |
| PubChem CID | 25144422 |
| Target Point | HBV |
| Passage | Anti-infection |
| Background | Morphotoiadin is an effective inhibitor of HBV replication. |
| Biological Activity | Morphothiadin is a potent inhibitor on the replication of both wild-type and adefovir-resistant HBV with an IC50 of 12 nM.[1-2] |
| IC50 | IC50: 12 nM (HBV)[1] |
| Data Literature Source | [1]. Zhou X， et al. Effects of ketoconazole and rifampicin on the pharmacokinetics of GLS4， a novel anti-hepatitis B virus compound， in dogs. Acta Pharmacol Sin. 2013 Nov;34(11):1420-6. [2]. Wu G， et al. Preclinical characterization of GLS4， an inhibitor of hepatitis B virus core particle assembly. Antimicrob Agents Chemother. 2013 Nov;57(11):5344-54. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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