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My CartCAS：1011529-10-4
Molecular Formula：C9H11FN6O4
Molecular Weight：286.22
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1011529-10-4 |
| Name | Azvudine |
| Molecular Formula | C9H11FN6O4 |
| Molecular Weight | 286.22 |
| Solubility | Soluble in Water/DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD26523134 |
| SMILES | C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@](O2)(CO)N=[N+]=[N-])O)F |
| InChIKey | KTOLOIKYVCHRJW-XZMZPDFPSA-N |
| InChI | InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17，14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2，5-7，17-18H，3H2，(H2，11，13，19)/t5-，6-，7+，9+/m0/s1 |
| PubChem CID | 24769759 |
| Target Point | NRTI;HIV;HBV;HCV |
| Passage | Anti-infection |
| Background | Azvudine is an effective nucleoside reverse transcriptase inhibitor (NRTI) with antiviral activity against HIV, HBV and HCV. |
| Biological Activity | Azvudine (RO-0622) is a potent nucleoside reverse transcriptase inhibitor (NRTI)， with antiviral activity on HIV， HBV and HCV. Azvudine exerts highly potent inhibition on HIV-1 (EC50s ranging from 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine inhibits NRTI-resistant viral strains[1]. |
| Data Literature Source | [1]. Wang RR，et al. Azvudine，a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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