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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > TGF-β/Smad > ML347CAS：1062368-49-3
Molecular Formula：C22 H16 N4 O
Molecular Weight：352.39
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 1062368-49-3 |
| Name | ML347 |
| Molecular Formula | C22 H16 N4 O |
| Molecular Weight | 352.39 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD28099805 |
| SMILES | COC1=CC=C(C=C1)C2=CN3C(=C(C=N3)C4=C5C=CC=NC5=CC=C4)N=C2 |
| InChIKey | FVRYPYDPKSZGNS-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H，1H3 |
| PubChem CID | 44577753 |
| Target Point | Activin receptor-like kinases (ALK1/2) |
| Passage | TGF-beta/Smad |
| Background | ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2， respectively， >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1[1-2]. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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