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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Metabolic Enzyme & Protease > ML-030CAS：1013750-77-0
Molecular Formula：C20H20N4O4S
Molecular Weight：412.46
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 1013750-77-0 |
| Name | ML-030 |
| Molecular Formula | C20H20N4O4S |
| Molecular Weight | 412.46 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| SMILES | COC1=CC(=C(C=C1)OC)C2=NN=C3N2N=C(CS3)C4=CC(=C(C=C4)OC)OC |
| InChIKey | DZAUSKKPHXFGNN-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H20N4O4S/c1-25-13-6-8-16(26-2)14(10-13)19-21-22-20-24(19)23-15(11-29-20)12-5-7-17(27-3)18(9-12)28-4/h5-10H，11H2，1-4H3 |
| PubChem CID | 17757146 |
| Target Point | PDE4 |
| Passage | Metabolic Enzyme&Protease |
| Background | ML-030 is an effective PDE4 inhibitor. |
| Biological Activity | ML-030 is a potent PDE4 inhibitor， with IC50 of 6.7 nM， 12.9 nM， 48.2 nM， 37.2 nM， 452 nM and 49.2 nM for PDE4A， PDE4A1， PDE4B1， PDE4B2， PDE4C1，and PDE4D2， respectively.[1] |
| IC50 | IC50: 6.7nM(PDE4A);12.9nM(PDE4A1);48.2nM(PDE4B1);37.2(PDE4B2)nM;452(PDE4C1)nM;49.2(PDE4D2)nM[1] |
| Data Literature Source | [1]. Skoumbourdis AP，et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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