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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Cell Cycle > ML346CAS：100872-83-1
Molecular Formula：C14H12N2O4
Molecular Weight：272.26
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 100872-83-1 |
| Name | ML346 |
| Molecular Formula | C14H12N2O4 |
| Molecular Weight | 272.26 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD01177921 |
| SMILES | COC1=CC=C(C=C1)/C=C/C=C2C(=O)NC(=O)NC2=O |
| InChIKey | IXYLVJHFJKDHRM-NSCUHMNNSA-N |
| InChI | InChI=1S/C14H12N2O4/c1-20-10-7-5-9(6-8-10)3-2-4-11-12(17)15-14(19)16-13(11)18/h2-8H，1H3，(H2，15，16，17，18，19)/b3-2+ |
| PubChem CID | 767276 |
| Target Point | Hsp70;HSF-1 |
| Passage | Cell Cycle;Metabolic Enzyme&Protease |
| Background | ML346 is an activator of Hsp70 and HSF-1. ML346 induces increased specificity of gene and protein effectors of heat shock response (HSR), including chaperones such as Hsp70, Hsp40 and Hsp27. |
| Biological Activity | ML346 is an activator of Hsp70 expression and HSF-1 activity， with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models， without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR)， including chaperones such as Hsp70， Hsp40， and Hsp27[1]. |
| IC50 | HSP70:4.6μM(EC50;HeLa cells)[1] |
| Data Literature Source | [1]. Calamini B，et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2012 Dec 17. [2]. Calamini B，et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8(2):185-96. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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