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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > NF-κB > BMS-345541 HydrochlorideCAS：547757-23-3
Molecular Formula：C14H18ClN5
Molecular Weight：291.78
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
Qty：
Size：
| CAS | 547757-23-3 |
| Name | BMS-345541 Hydrochloride |
| Molecular Formula | C14H18ClN5 |
| Molecular Weight | 291.78 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07784499 |
| SMILES | CC1=CC2=C(C=C1)N=C(C3=NC=C(N23)C)NCCN.Cl |
| InChIKey | MIDKPVLYXNLFGZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C14H17N5.ClH/c1-9-3-4-11-12(7-9)19-10(2)8-17-14(19)13(18-11)16-6-5-15;/h3-4，7-8H，5-6，15H2，1-2H3，(H，16，18);1H |
| PubChem CID | 9926054 |
| Target Point | IKK |
| Passage | NF-κB |
| Background | It is a selective IKK catalytic subunit IKK-1 and IKK-2 inhibitor. |
| Biological Activity | BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC50=0.3 μM， IKK-1 IC50=4 μM). BMS-345541 binds at an allosteric site of IKK.[1-3] |
| Data Literature Source | [1]. Burke JR， et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem， 2003， 278(3)， 1450-1456. [2]. Yang J， et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res， 2006， 12(3 Pt 1)， 950-960. [3]. MacMaster JF， et al. An inhibitor of IkappaB kinase， BMS-345541， blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res， 2003， 52(12)， 508-511. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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