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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Protein Tyrosine Kinase/PTK > MLR-1023CAS：41964-07-2
Molecular Formula：C11H10N2O2
Molecular Weight：202.21
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Solid
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| CAS | 41964-07-2 |
| Name | MLR-1023 |
| Molecular Formula | C11H10N2O2 |
| Molecular Weight | 202.21 |
| Solubility | Soluble in DMSO |
| Purity | ≥98% |
| Appearance | Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00866900 |
| SMILES | CC1=CC(=CC=C1)OC2=CNC(=O)N=C2 |
| InChIKey | HJQILFPVRNHTIG-UHFFFAOYSA-N |
| InChI | InChI=1S/C11H10N2O2/c1-8-3-2-4-9(5-8)15-10-6-12-11(14)13-7-10/h2-7H，1H3，(H，12，13，14) |
| PubChem CID | 39065 |
| Target Point | Lyn kinase |
| Passage | Protein Tyrosine Kinase/RTK |
| Background | Tolimidone is an effective and selective Lyn kinase allosteric activator. |
| Biological Activity | Tolimidone is a potent and selective allosteric activator of Lyn kinase with an EC50 of 63 nM.[1-2] |
| IC50 | EC50: 63 nM (Lyn kinase)[1] |
| Data Literature Source | [1]. Saporito MS， et al. MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J Pharmacol Exp Ther. 2012 Jul;342(1):15-22. [2]. Ochman AR， et al. The Lyn kinase activator MLR-1023 is a novel insulin receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J Pharmacol Exp Ther. 2012 Jul;342(1):23-32. |
| Unit | Bottle |
| Specification | 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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