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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Immunology & Inflammation > 2',3'-cGAMP sodium saltCAS：2734858-36-5
Molecular Formula：C20H22N10Na2O13P2
Molecular Weight：718.37
Storage：Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 2734858-36-5 |
| Name | 2'，3'-cGAMP sodium salt |
| Molecular Formula | C20H22N10Na2O13P2 |
| Molecular Weight | 718.37 |
| Solubility | Soluble in Water(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，1 year;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD31563596 |
| SMILES | C1C2C(C(C(O2)N3C=NC4=C3N=C(NC4=O)N)OP(=O)(OCC5C(C(C(O5)N6C=NC7=C(N=CN=C76)N)O)OP(=O)(O1)[O-])[O-])O.[Na+].[Na+] |
| InChIKey | CNVCOPPPOWRJAV-DQNSRKNCSA-L |
| InChI | InChI=1S/C20H24N10O13P2.2Na/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36，37)43-13-10(31)6(1-38-44(34，35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33;;/h3-7，10-13，18-19，31-32H，1-2H2，(H，34，35)(H，36，37)(H2，21，23，24)(H3，22，27，28，33);;/q;2*+1/p-2/t6-，7-，10-，11-，12-，13-，18-，19-;;/m1../s1 |
| PubChem CID | 137120248 |
| Target Point | STING;IFNβ |
| Passage | Immunology & Inflammation |
| Background | 2, 3- cGAMP sodium salt combines STING with high affinity and is interferon- β (IFN β) Effective inducer. |
| Biological Activity | 2'，3'-cGAMP sodium (2'-3'-cyclic GMP-AMP sodium) is a endogenous cGAMP in mammalian cells. 2'，3'-cGAMP sodium binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2'，3'-cGAMP sodium is produced in mammalian cells in response to DNA in the cytoplasm[1]. |
| Data Literature Source | [1]. Zhang X，et al. Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING. Mol Cell. 2013 Jul 25;51(2):226-35. |
| Unit | Bottle |
| Specification | 1mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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